Enigmatic Variations

Enigmatic variations: divergent modes of regulating eukaryotic DNA replication.

Proteins involved in DNA replication are conserved from yeast to mammals, suggesting that the mechanism was established at an early stage of eukaryotic evolution. In spite of this common origin, recent findings have revealed surprising variations in how replication initiation is controlled, implying that a conserved mechanism has not necessarily resulted in regulatory conservation.

[An enigmatic eye in an enigmatic bust].

have read with interest the article published in the iconoraphic section of this Journal by Drs. Diez-Lage and González nd titled The enigmatic eye of Nefertiti.1 After publishing a eview on the topic in the February issue of the British Journal f Ophthalmology,2 I would like to make a few comments. Queen Nefertiti (c. 1370–1330 AC) was the Great Royal Wife f Akhenaton (Amenhotep or Amenophis I...

Those enigmatic NG2 cells . . . .

The enigmatic xenopsins

A new member of the family of light-sensitive proteins called opsins has stirred up our view of photoreceptors.

Neuroblastoma: an enigmatic disease.

Neuroblastoma is the most common extra-cranial solid tumor of childhood. It originates in cells of the neural crest, and so can be found anywhere along the paravertebral sympathetic chain or in the adrenal gland. In the last 15 years, new developments in the genetics and biology of neuroblastoma, have led to a better understanding of the natural history and prognostic features of this cancer. T...